Life and aging with HIV

An interdisciplinary approach

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A monograph on the epidemiology and course of HIV infections, neuroimaging diagnostics, and the cognitive adaptation (psychological functioning) of people infected with HIV, as well as their aging processes – with a particular emphasis on their olfactory and auditory functions and metabolic bone diseases. The authors - neuropsychologists, psychiatrists, radiologists, and audiologists - present the results of their own research and a reliable and critical review of the current body of literature. This publication is addressed to psychologists and caregivers of people infected with HIV.


Angielskojęzyczne wydanie elektroniczne monografii poświęconej epidemiologii i przebiegowi zakażeń HIV, diagnostyce neuroobrazowej, funkcjonowaniu psychicznemu oraz procesom starzenia, ze szczególnym uwzględnieniem funkcji węchowych i słuchowych oraz metabolicznych chorób kości u osób zakażonych wirusem HIV.


Publikacja wyjątkowa ze względu na kompleksowość oraz interdyscyplinarność poruszanej w niej problematyki – autorami zebranych w niej tekstów są specjaliści w takich dziedzinach, jak neuropsychologia, psychiatria, radiologia, audiologia i inne. Jako jedyna jak dotąd monografia w Polsce prezentująca kwestie związane z zakażeniami HIV, zawierająca rzetelny i krytyczny przegląd aktualnej literatury i opisująca wyniki własnych badań autorów znajdzie z pewnością ważne miejsce w procesie kształcenia i doskonalenia kadr medycznych i psychologów, zajmujących się opieką nad osobami zakażonymi HIV.


Liczba stron318
WydawcaUniwersytet Warszawski
ISBN-13978-83-235-3513-3
Numer wydania1
Język publikacjiangielski
Informacja o sprzedawcyePWN sp. z o.o.

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  Contents
  Introduction
  References
  PART I Treatment vs new portrait of the HIV epidemic
  CHAPTER 1 Epidemiology of HIV infection in Poland in light of the situation in Europe and worldwide
  Conclusions
  References
  CHAPTER 2 Tolerance of the antiretroviral treatment vs aging of the individuals living with HIV
  Summary
  References
  PART II RESEARCH ON THE BRAIN IN HIV INFECTION – CURRENT CHALLENGES
  CHAPTER 3 Aging of the brain in HIV infection
  Introduction
  Physiological aging of the brain
  Morphological exponents of changes in the brain due to aging
  Immune response changes associated with age
  Neurobiochemical changes in the aging brain
  Changes in the central nervous system in HIV infection
  Entering of HIV into the CNS
  Destruction of nerve cells
  Compartmentalization of HIV in the CNS
  Chronic inflammation of the CNS and activation of the immune system
  Pathomorphological changes in the CNS
  Neuroimaging studies
  Clinical manifestations of HIV infection in the CNS
  Antiretroviral therapy and the CNS
  Factors influencing brain aging in HIV-infected patients
  Age of HIV-infected patients
  Processes affecting aging of the brain
  ART in elderly patients
  Clinical symptoms of brain aging in HIV-infected individuals
  References
  CHAPTER 4 The use of magnetic resonance imaging in diagnosing and monitoring cerebral lesions in
  HIV-infected patients while taking into account the aging processes
  Introduction
  Neuroimaging methods and techniques using magnetic resonance imaging
  Conventional structural imaging
  Mapping the diffusion tensor parameters
  Functional imaging
  In vivo spectroscopy
  Organic changes in the brain in HIV-infected patients as observed with MR imaging
  The processes of brain aging in MR images
  Summary
  References
  CHAPTER 5 Magnetic resonance spectroscopy studies in patients infected with HIV
  Introduction
  Proton magnetic resonance spectroscopy
  Metabolites measured with the use of MRS
  MRS applications in research on the effects of HIV infection and aging of the central nervous system
  Aging process and HMRS spectrum in healthy as well as HIV-infected individuals
  Aging process and HMRS spectrum in HIV-infected individuals
  The use of the MRS technique in neuroimaging of the neuropsychological deficits associated with
  HIV infection
  Summary
  References
  CHAPTER 6 Mapping brain abnormalities in aging HIV-infected individuals. A review of neuroimaging
  4
  studies
  Introduction
  Structural magnetic resonance imaging studies of the HIV-infected brain
  Functional magnetic resonance imaging studies of the HIV-infected brain
  fMRI, HIV and aging
  Application of PET in examining the HIV-infected brain
  Application of PET in examining aging HIV-positive subjects
  Conclusions
  References
  CHAPTER 7 Relationship between white matter integrity and neurocognitive outcomes in human
  immunodeficiency virus (HIV)
  Background
  Method
  Database search
  Participants
  Methodology
  DTI analysis
  Neuropsychology
  Results
  General DTI results
  DTI correlation with neuropsychology
  DTI and the global neuropsychological score relationship
  Specific neurocognitive tests
  Processing speed
  Verbal learning
  Attention interference
  Prospective memory
  Mental control
  Hierarchical perception
  No relationship between DTI and neuropsychology
  Discussion
  References
  Appendix 1 Pubmed search syntax
  Appendix 2 Participants
  Appendix 3 DTI Methodology
  Appendix 4 Neuropsychology testing
  CHAPTER 8 Aging of the brain in HIV infection: literature review of the studies using resting state
  functional magnetic resonance imaging
  Introduction
  Assumptions underlying RS-fMRI research paradigm
  Changes in the spontaneous brain activity related to aging
  Changes in the spontaneous brain activity in individuals aging with HIV infection
  The relationship between RS of the brain and neurocognitive functioning in HIV infection
  Summary
  References
  PART III Psychological problems in HIV-infected individuals Nature Reviews
  CHAPTER 9 Depressive disorders in individuals with HIV infection in the context of aging
  Introduction
  Depressive disorders in HIV-infected people
  Depressive disorders in the elderly
  Aging of HIV-infected people
  Summary
  References
  CHAPTER 10 Factors determining neuropsychological functioning in individuals who live with HIV/AIDS
  Introduction
  Biological factors
  Psychological factors
  Depression
  Anxiety disorders
  5
  Personality Disorders
  HIV infection and psychoactive substance addiction
  Demographic factors
  Summary
  References
  CHAPTER 11 Quality of life in persons with HIV infection
  Introduction
  Research methods for assessing quality of life in HIV-infected patients
  Determinants of quality of life in HIV-infected persons
  HRQoL and demographic variables
  HRQoL and social and emotional functioning
  HRQoL and mental health
  HRQoL and cognitive functioning
  HRQOL and HIV infection variables
  Summary
  References
  CHAPTER 12 Cognitive reserve, psychosocial and lifestyle factors and the risk of neurocognitive
  impairment in older HIV-infected adults
  Introduction
  Cognitive aging in HIV infection
  Impact of reserve and lifestyle factors on neuropsychological functioning in older individuals
  infected with HIV
  Cognitive reserve
  Medication adherence
  Substance use cessation and nutrition
  Employment
  Social participation and attitude
  Physical activity
  Summary
  References
  CHAPTER 13 Research on the psychological help available for HIV-infected individuals
  Introduction
  Psychiatric disorders and emotional problems of infected people
  Psychotherapy of people infected with HIV
  Evidence-based therapy approach in patients living with HIV
  From evidence-based to constructivist forms of psychotherapy
  Psychotherapy of HIV-infected older adults
  Summary
  References
  Empirical research reports
  CHAPTER 14 Age and trauma symptoms intensity and social support in HIV-positive individuals
  Introduction
  Methods
  Participants
  Assessment
  Statistical analysis
  Results
  Discussion
  Acknowledgements
  References
  CHAPTER 15 Age vs state of cognitive processes in individuals with HIV/HCV co-infection. Empirical
  research
  Introduction
  Classification of HIV-associated cognitive impairment
  Cognitive impairment associated with HCV infection
  Cognitive impairment associated with HIV and HCV co-infection
  Empirical research
  Introduction to empirical research
  Methods
  Participants
  6
  Measurement
  Statistical analysis
  Results
  Discussion
  Conclusions
  References
  CHAPTER 16 Psychological functioning in HIV/HCV co-infected and HCV mono-infected individuals
  following hepatitis C treatment
  Introduction
  Study design and testing procedure
  Participants
  Clinical characteristics
  Variables related to HCV infection
  HIV-related variables
  Other clinical variables
  Methods of psychological assessment
  Statistical analysis
  Results
  Cognitive functions
  Mood, fatigue and quality of life
  Clinical variables vs psychological tests results
  Discussion and conclusions
  References
  Appendix 1.
  Appendix 2. Outcomes on the measurement of depression, fatigue and health-related quality of life
  in the studied groups at three measurements: before treatment, at week 12, and after completion of
  therapy
  PART IV Selected problems
  CHAPTER 17 Olfaction capacity – emerging clinical research area in HIV infection
  Introduction
  Significance of olfactory capacity in humans
  Olfactory capacity components and methods of examining them
  Olfactory Abnormalities
  Research on the olfactory capacity in HIV-infected individuals
  Summary
  References
  CHAPTER 18 Auditory functions in HIV-infected adults
  Introduction
  Hearing loss in HIV infection
  Age and hearing loss in HIV infection
  HAART and hearing loss in HIV infection
  Central auditory deficits in HIV infection
  Tinnitus in HIV infection
  Vestibular symptoms in HIV infection
  Auditory and cognitive functions in HIV infection
  Conclusions
  References
  CHAPTER 19 Metabolic bone diseases in HIV-infected patients
  Introduction
  Bone tissue – regulatory factors
  Bone mineral density
  Osteopenia and osteoporosis in HIV-infected individuals
  Pathophysiology of bone mass loss in HIV infection
  Bone fracture risk in HIV+ individuals
  Therapeutic options
  Conclusions
  References
  Authors
RozwińZwiń
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